Si-Wu-Tang improves liver fibrosis by restoring liver sinusoidal endothelial cell functionality and reducing communication with hepatic stellate cells
SWT collectively ameliorated liver fibrosis by inhibiting the COL8A1/IL-1β/OLR1 pathways associated with LSEC angiogenesis, adhesion and defenestration, as well as suppressing LSEC secretion of IL-1β to reduce HSC activation.
Authors
- J Li (ORCID: https://orcid.org/0000-0003-3177-4335)
- Xiaoyong Xue (ORCID: https://orcid.org/0000-0001-9001-4569)
- Xiaohong Mu (ORCID: https://orcid.org/0000-0002-0075-2320)
- Lingling Qin (ORCID: https://orcid.org/0000-0003-3255-6663)
- Yufei Li (ORCID: https://orcid.org/0000-0001-5940-4606)
- Jiaorong Qu
- Xiaojiaoyang Li (ORCID: https://orcid.org/0000-0002-8997-9651)
- Le Wang (ORCID: https://orcid.org/0000-0002-7155-7549)
- Yuanfeng Dou
Institutions
- Beijing University of Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s13020-024-01038-1
- Citations
- 5
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities