Formulation and Evaluation of Propranolol Hydrochloride Floating Tablets by 32 Factorial Design

The goal of current work is to develop Propranolol HCl floating tablets. Floating tablets of Propranolol HCl were designed basing on the idea of gas generation. Using sodium bicarbonate (NaHCO3) as a gas-generating agent, xanthan gum, polyox WSR 303a as a matrix-forming polymer, and HPMC K4 M and K15 M as matrix-forming polymers, matrix tablets totalling 40 mg of propranolol HCl were created.Among the four polymers namely HPMCK4M, HPMCK15M, Xanthan gum and Polyox WSR, HPMC K4M gave good release and was selected for formulation of propranolol HCl floating tablets by 32 factorial design. Propranolol HCl release from the manufactured floating tablets occurred gradually over the course of 12 hours and was contingent upon the tablet's composition. The percentage that the independent variables HPMC K4M and NaHCO3 were utilised in the formulation of propranolol HCl floating tablets is described by a chosen three level, two factors experimental designs (32 factorial designs). Floating lag time (FLT), percent drug released in 8h were selected as dependent variables. The equations for Floating lag time (FLT) and drug release in 8 hr in (PD8) drug dissolved are as follows. Y1= 23.89 +4.17X1 -8.33 X2-0.75X1X2 +0.17X12 +2.67X22 (FLT), Y2= 81.06 -1.86X1 -4.10X2 -0.14 X1X2 – 0.21X12 + 6.57 X22 (DR8h). The Y1 equations' co-efficient of X2, which has a negative sign, shows that floating lag time increases as sodium bicarbonate concentration falls. The findings indicatethat the amount of NaHCO3 (X2) and the amount of HPMCK4M (X1) both have an impact on how long it takes for a medication to release and floating lag time.All manufactured floating tablet drug release followed first order kinetics, with the exception of F7, F8, and F9. Drug release from all the floating tablets prepared followed first order kinetics except in case of F7, F8 and F9. All manufactured floating tablets had their drug release regulated by non-Fickian diffusion, which served as the floating tablet's release mechanism. For FLT and DR 8h, the proximity between the predicted and observed values supports the rationality of the consequent equations for the dependent variables. Among the nine formulations F9 formulation is considered as best formulation basing on floating lag time and medication release parameters. It can be inferred from the findings that the floating tablets of propranolol HCl can be obtained successfully using optimization by 32 factorial design using HPMC K4M and sodium bicarbonate.