Optimization of Telmisartan Loaded Locust Bean Gum and Thiolated Chitosan Hydrogel Using Central Composite Design

This article describes the formulation of a mucoadhesive thiolated chitosan (TC) and Locust Bean Gum (LBG) hydrogel for the application of site-targeted delivery of telmisartan. The hydrogel was formulated using the tripolyphosphate (TPP) ionotropic gelation cross-linking procedure. The optimized IPN hydrogel was considered by FTIR, UV-visible and SEM. And in vitro drug release abilities and mucoadhesion properties were also evaluated. The effect of polymer blend ratio on swelling capacity was investigated. The improved formulation demonstrated long-lasting drug release (up to 12 hours) and excellent mucoadhesiveness. A non-fickian technique was used to monitor the drug release from the hydrogel. The study's findings suggest that LBG:TC hydrogel could be a good vehicle for targeted medication delivery.