Formulation and Evaluation of Pulsatile Drug Delivery System by Press Coating Method for Treatment of COPD (Asthma)

The press coating approach has been employed in the current study; this system involves compressing directly of both core as well as the coat. The procedure is the same: first, we make the core tablet containing drug, diluent, binder, Crospovidone as superdisintegrant for burst release after lag time, glidant, and lubricant in an 8mm die. After that, we get the Eudragit S 100 as polymer in different ratios and divide it into two equal parts, subsequently the lower half is inserted in a cavity in 10mm die followed by core tablet has been placed in the middle, and the other half portion that comprises the coat is filled in the die cavity. Powder's assessment parameters were judged to be within an appropriate range. Overall, the evaluation results for the core and press-coated tablets passed within acceptable parameters. Optimized batch F7 shows 99.07% drug release. Optimized batches are further evaluated for tests like FTIR, DSC, and Stability study as per standard ICH guidelines. From all result conclude that as per concentration of superdisintegrant increases % drug release also increases after the lag time. Eudragit S 100 acts good lag time polymer release drug only at after pH 7 means colon target was done hence successfully pulsatile drug delivery was performed.