Nanoniosomes Loaded with Catechin for Anticancer Activity on Hepatoma HepG2 Cells

This study focuses on formulation and assessment of catechin-loaded nanoniosomes and their cytotoxicity against HepG2 hepatoma cells. Catechin, a natural antioxidant with potential anticancer properties, has limited clinical use due to its poor bioavailability and stability. Using thin-film hydration approach, nanoniosomes were produced and characterised for encapsulation efficiency, particle size, and zeta potential in order to address these obstacles. cytotoxic activity of catechin-loaded nanoniosomes was assessed on HepG2 cells using MTT assay, and results were compared to free catechin and the chemotherapeutic drug cisplatin. The nanoniosomes demonstrated improved encapsulation efficiency and sustained release properties. Furthermore, catechin-loaded nanoniosomes exhibited significantly enhanced cytotoxicity against HepG2 cells compared to free catechin, and cisplatin. This study highlights the potential of nanoniosomal systems in improving the therapeutic efficacy of catechin for hepatocellular carcinoma treatment.