Formulation and Evaluation of Mucoadhasive Tablets by using Thiolated Cassia sophera Seed Polysaccharide as A Bioadhasive Material

Objective of current investigation is extraction and chemical modification of seed polysaccharide from seeds of Cassia sophera. Isolated and modified polysaccharide was evaluated for phytochemical investigation, degree of thiol group substitution, FTIR, DSC, XRD, Zeta Potential. Ondansetron hydrochloride, was selected for formulation of mucoadhesive buccal tablet consisting natural and thiolated seed polysaccharide. The study investigated the physicochemical characteristics of extracted and modified seed polysaccharide as a suitable mucoadhesive agent When comparing modified and untreated tablets, the ones with the strongest mucoadhesive strength were those whose concentrations of modified polymer rose with time. Mucoadhesive ondansetron tablets are made in this study by using thiolated Cassia sophera to treat emesis. The formulation has been manufactured successfully and exhibits optimal drug release to yield the intended therapeutic effects.