Design, Fabrication and Evaluation of Vildagliptin Loaded Crosslinked Sodium Alginate and Guar Gum Microspheres

Vildagliptin is an Anti-hyperglycemic drug. This study was based on fabrication and evaluation of Vildagliptin loaded microspheres by ionotropic gelation method. Overall six batches of microspheres with sodium alginate and guar gum microspheres had been composed and evaluated for particle size measurement with digital microscope, percentage yield, swelling index, determination of drug entrapment, scanning electron microscopic image, In Vitro release study of drug and release kinetics. Novelty of this study is use of different concentrations of counter ion solution and comparing improvement in drug diffusion. Evaluation studies showed that particle sizes of microspheres ranged within 0.7 to 1.1 mm, as well as scanning electron microscopy also showed good reports. Highest percentage yield was achieved for F1 that was 88.17 %. Swelling indexes were promising for all batches but the highest value noticed for F2. Drug entrapment efficiency results showed a way up value for F5. Drug release kinetic results for all six formulations indicated notable responses for Korsmeyer Peppas and Higuchi Model rather than other models. F1 gave the most mesmerizing report for Korsmeyer Peppas and Higuchi Model with diffusion controlled mechanism.