Development and assessment of Carboxymethylated Galactomannan from Seeds of Caesalpinia pulcherrima as an Efficient Disintegrating Agent for Orally Disintegrating Tablet

Current study's objective was to evaluate the disintegration potential of naturally occurring Caesalpinia pulcherrima seedgalactomannan and to chemically modify it for formulation of orally disintegrating tablet formulation. Galactomannan extracted from the Caesalpinia pulcherrima seeds received chemical modification through carboxymethylation in an effort to enhance its hydrophilic nature of galactomannan which enhances disintegration potency. Carboxymethylated Caesalpinia pulcherrima seed galactomannan synthesized by etherification process by using monochloroacetic acid the titrimetric method was used to measure the extent of substitution. Carboxymethyl modification of galactomannan was analysed by, various methods like Zeta potential measurement, DSC thermogramand FT-IR. Ondansetron ODT were prepared separately using isolated and carboxymethylated Caesalpinia pulcherrima seed galactomannan by incorporating different concentrations such as 2, 4, 6 %. Precompression and post compressional evaluation parameters for formulated batches were compared with two ethical marketed formulations. Modified Caesalpinia pulcherrima seed galactomannan was nearly equivalent to reference formulation in quality testing so this work makes modified galactomannan suitable disintegrating agent in tablet formulation. As a conclusion, it can be said thatcarboxymethylated galactomannan from seeds of Caesalpinia pulcherrima is suitable disintegrating agent for ODTs.