Disproportionality Analysis of Hepatotoxic and Gastrointestinal Adverse Events Associated With Nintedanib Using the Japanese Adverse Drug Event Report (JADER) Database

Nintedanib is more likely to cause elevated liver enzyme levels, diarrhea, and decreased appetite than other drugs. These events occurred within approximately 3-4 months. The concomitant use of prednisolone may also be associated with gastrointestinal hemorrhage.

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Publication Details

Journal
In Vivo
Published
2024-12-31
DOI
https://doi.org/10.21873/invivo.13841
Citations
1
Primary Topic
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Type
article
Field-Weighted Citation Impact
0.42
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article

Disproportionality Analysis of Hepatotoxic and Gastrointestinal Adverse Events Associated With Nintedanib Using the Japanese Adverse Drug Event Report (JADER) Database

Kenta Yamaoka, Hiroaki Ikesue, Masaki Fujiwara, Yoshihiro Uesawa et al.
1 citations
In Vivo
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
0.42
article

Disproportionality Analysis of Hepatotoxic and Gastrointestinal Adverse Events Associated With Nintedanib Using the Japanese Adverse Drug Event Report (JADER) Database

Kenta Yamaoka, Hiroaki Ikesue, Masaki Fujiwara, Yoshihiro Uesawa, Tadashi Shimizu, Nobuyuki Muroi, Mayako Uchida
article en
1 citations

Abstract

Nintedanib is more likely to cause elevated liver enzyme levels, diarrhea, and decreased appetite than other drugs. These events occurred within approximately 3-4 months. The concomitant use of prednisolone may also be associated with gastrointestinal hemorrhage.

In VivoVol. 39(1)
Meiji Pharmaceutical University (JP), Kobe City Medical Center General Hospital (JP), Kobe University (JP), Doshisha Women's College of Liberal Arts (JP), Hyogo University (JP)
Good health and well-being
Openalex Percentile: Top 29%
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
0.42
DOIOpen Access PDFOpenAlex
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Disproportionality Analysis of Hepatotoxic and Gastrointestinal Adverse Events Associated With Nintedanib Using the Japanese Adverse Drug Event Report (JADER) Database — Kenta Yamaoka, Hiroaki Ikesue, et al. · In Vivo (2024) | TGRS Research Map | TGRS