The Combination of Tumor-targeting<i>Salmonella typhimurium</i>A1-R Plus the Autophagy-inhibitor Chloroquine Synergistically Eradicates HT1080 Fibrosarcoma Cells<i>In Vitro</i>and<i>In Vivo</i>
The combination treatment of A1-R plus chloroquine demonstrated synergy against HT1080 cancer cells in vitro and in vivo. A1-R was administered orally, suggesting its potential as a probiotic. The present results suggest the clinical potential of the combination of A1-R and chloroquine for soft-tissue sarcoma therapy, a recalcitrant disease.
Authors
- Michael Bouvet (ORCID: https://orcid.org/0000-0002-0086-2159)
- Shinji Miwa (ORCID: https://orcid.org/0000-0002-5962-8287)
- Byung Mo Kang (ORCID: https://orcid.org/0000-0003-0900-094X)
- Katsuhiro Hayashi (ORCID: https://orcid.org/0000-0001-8665-2154)
- Norio Yamamoto (ORCID: https://orcid.org/0000-0002-0622-5441)
- Takashi Higuchi (ORCID: https://orcid.org/0000-0003-2896-4939)
- Hiroyuki Tsuchiya (ORCID: https://orcid.org/0000-0003-0730-7921)
- KOHEI MIZUTA
- Satoru Demura
- HIROAKI KIMURA
- Kentaro Igarashi (ORCID: https://orcid.org/0000-0003-2278-1736)
- Ming Zhao (ORCID: https://orcid.org/0000-0002-1025-8895)
- Sei Morinaga (ORCID: https://orcid.org/0000-0003-2961-9432)
- Robert M. Hoffman
Institutions
- Kanazawa University (JP)
- University of California San Diego (US)
- AntiCancer (United States) (US)
Publication Details
- Journal
- In Vivo
- Published
- 2024-12-31
- DOI
- https://doi.org/10.21873/invivo.13807
- Citations
- 1
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.39