Assessment of InDel Variations in CPT1A and PRDM6 Genes Across Three Anatolian Goat Populations

Identifying candidate genes associated with growth traits in livestock and incorporating them into Marker Assisted Selection (MAS) studies, in addition to classical selection methods, can increase genetic progress and thus profitability. Carnitine Palmitoyl Transferase 1a (CPT1a) and PR domain family 6 (PRDM6) are among the candidate genes reported to be associated with growth traits in goats. This study aimed to identify polymorphisms in the CPT1a and PRDM6 genes related to growth traits in Kıl (HAI), Honamlı (HNM), and Kabakulak (KBK) goats, and to discuss their potential use in MAS studies. The II genotype of the CPT1a gene was not found in the HNM or KIL goats, whereas the KBK population included all three genotypes (II, ID, and DD). The frequency of the ID genotype ranged from 0.25 (HAI) to 0.40 (KBK), while the DD genotype frequency ranged from 0.37 (KBK) to 0.75 (HAI). For the PRDM6 gene, the KBK population was found to be monomorphic, containing only the DD genotype. Although the II genotype was not detected in the HNM and HAI breeds, the ID genotype frequencies were calculated as 0.05 and 0.07, respectively. The study's findings point out that the CPT1a gene can be used in MAS studies for HNM, KBK, and HAI goats, whereas the PRDM6 gene cannot be utilized.