Increased quality of life indices among sepsis survivors rehabilitated in the RehaSep trial

<b>Objective:</b> In this study, the gap was addressed in effective rehabilitation methodologies for preventing sepsis sequelae utilising a novel, two-way, diagnostically-monitored personalised rehabilitation model implemented to enhance quality of life (QoL) among sepsis survivors. <br><b>Methods:</b> Of 66 sepsis survivors post-hospital discharge, and those who met the inclusion criteria, 30 were eventually allocated into three groups: a control group (Group C, n = 10, no rehabilitation) and two intervention groups undergoing three-month, diagnostically-monitored rehabilitation programmes. Group E (n = 10) received personalised aerobic and functional training, while Group H (n = 10) underwent intermittent hyperbaric oxygen therapy as a novel rehabilitative treatment alternative. QoL was evaluated at hospital discharge and again after 3 months using the newly developed Life After Sepsis Survey.<br><b>Results:</b> After three months, statistically significant (<i>p</i> < 0.05) improvement was observed in QoL among sepsis survivors from both intervention groups concerning the significant parts of the assessed physiological, physical and psychological functions. <br><b>Conclusions:</b> The personalised, patient-centric and supportive approach significantly improved QoL among sepsis survivors, highlighting the potential effectiveness of this rehabilitation model. The Life After Sepsis proved to be a practical assessment tool and currently stands as a uniquely suitable measure for evaluating sepsis rehabilitation outcomes.