GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis
Our results not only provide a novel mechanism for TNBC metastasis but also offer a new therapeutic strategy to combat metastatic TNBC via targeting GRK6 activity.
Authors
- Yuan‐Feng Lin (ORCID: https://orcid.org/0000-0003-4456-0766)
- Che-Hsuan Lin
- Hsun‐Hua Lee (ORCID: https://orcid.org/0000-0002-1473-4799)
- Hui‐Wen Chiu (ORCID: https://orcid.org/0000-0002-5027-390X)
- Yen‐Lin Chen (ORCID: https://orcid.org/0000-0003-1149-394X)
- Wenke Wang (ORCID: https://orcid.org/0000-0003-1688-638X)
- Yu-Hsien Kent Lin
- Hui-Yu Lin (ORCID: https://orcid.org/0000-0003-0197-6075)
- Shry-Ming Sheen-Chen
Institutions
- Fu Jen Catholic University (TW)
- Tri-Service General Hospital (TW)
- The University of Sydney (AU)
- Royal North Shore Hospital (AU)
- Taipei Medical University Hospital (TW)
- Northern Sydney Local Health District (AU)
- Breast Center (CH)
- Wan Fang Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s13058-024-01953-z
- Citations
- 4
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Science and Technology Council