Association of Serum Polyunsaturated Fatty Acids (PUFAs) and Children’s Dietary Inflammatory Index (C-DIITM) with Recurrent Respiratory Infections in Children: A Cross-Sectional Study

To assess the associations between serum and dietary polyunsaturated fatty acids (PUFAs), as well as the inflammatory potential of diet measured by the Children's Dietary Inflammatory Index (C-DII^TM), and recurrent respiratory infections (RRIs) in children. We enrolled 44 children aged 3-16 years with RRIs and 44 healthy controls. Dietary intake was assessed using a 7-day food record from which PUFA intake and C-DII^TM were calculated. Serum PUFA levels were determined using gas-liquid chromatography-mass spectrometry. The dietary assessment showed a significantly lower fiber intake in children with RRIs. The RRI group had a higher inflammatory potential in the diet than healthy controls. Children with RRIs have higher serum levels of linoleic, arachidonic, and eicosapentaenoic acids than healthy subjects. A pro-inflammatory diet was positively associated with serum <i>n</i>-6 PUFA levels in both the groups. A high inflammatory potential of diet, body mass index over 75 percentile, and short breastfeeding duration were identified as risk factors for RRIs. The inflammatory potential of diet is strongly associated with RRIs in children and related to their PUFA status. Promoting breastfeeding and healthy dietary habits during childhood are crucial for implementing effective preventive management strategies.