Post-translational modifications on protein VII are important during the early stages of adenovirus infection
Adenoviruses are ubiquitous human pathogens that cause a variety of diseases, such as respiratory infections, gastroenteritis, and conjunctivitis. While often viewed as a self-limiting infection in healthy individuals, adenoviruses are particularly harmful to immunocompromised patients. Here, we investigate the functional role of post-translational modifications (PTMs) on an essential adenovirus core protein, protein VII, describing how they regulate its function during the early and late stages of infection. Our study focuses on how specific PTMs on protein VII influence transcription, localization, and interactions with other proteins, highlighting how PTMs are employed by viruses to alter protein function.
Authors
- Daphne C. Avgousti (ORCID: https://orcid.org/0000-0002-1700-3959)
- Monica S. Guo (ORCID: https://orcid.org/0000-0002-6720-2323)
- Laurel Kelnhofer-Millevolte (ORCID: https://orcid.org/0000-0002-1635-1222)
- Edward A. Arnold (ORCID: https://orcid.org/0000-0002-3057-1117)
- Jason G. Smith (ORCID: https://orcid.org/0000-0001-6727-5269)
- Katie Leung
- Julian R. Smith (ORCID: https://orcid.org/0000-0002-8167-4335)
- Daniel H. Nguyen
Institutions
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- University of Washington (US)
- University of Washington Medical Center (US)
- Fred Hutch Cancer Center (US)
Publication Details
- Journal
- Journal of Virology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1128/jvi.01462-24
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Washington
- Strong
- National Institutes of Health