Validation of a simplified HPV genotyping assay designed for cervical screening in low-resource settings
This work validates a novel pre-packed formulation for the ScreenFire human papillomavirus (HPV) assay, which has the potential to simplify the HPV testing process and to reduce the chances of post-amplification contamination, providing a simpler, low-cost, near-point-of-care HPV testing, and extended genotyping solution for cervical screening in resource-limited settings as part of the ultimate public health goal to accelerate cervical cancer prevention. This technology can also have broad applications for other DNA amplification assays beyond HPV.
Authors
- Sílvia de Sanjosé (ORCID: https://orcid.org/0000-0002-5909-676X)
- Clement A. Adepiti (ORCID: https://orcid.org/0000-0001-7210-6670)
- Kanan Desai (ORCID: https://orcid.org/0000-0002-8992-5944)
- Kayode Olusegun Ajenifuja (ORCID: https://orcid.org/0000-0001-9823-5892)
- Didem Egemen (ORCID: https://orcid.org/0000-0001-5617-4585)
- Federica Inturrisi (ORCID: https://orcid.org/0000-0002-3661-0842)
- Nicolas Wentzensen (ORCID: https://orcid.org/0000-0003-1251-0836)
- Casey Dagnall (ORCID: https://orcid.org/0000-0001-7334-4718)
- Julia C. Gage (ORCID: https://orcid.org/0000-0001-5259-6385)
- Amanda Hoffman (ORCID: https://orcid.org/0009-0009-9186-5301)
- Mark Schiffman (ORCID: https://orcid.org/0000-0001-9000-9671)
Institutions
- Leidos (United States) (US)
- Norwalk Hospital (US)
- Ekiti State University (NG)
- Adekunle Ajasin University (NG)
- Barcelona Institute for Global Health (ES)
- Obafemi Awolowo University (NG)
Publication Details
- Journal
- Journal of Clinical Microbiology
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1128/jcm.01639-24
- Citations
- 3
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institutes of Health
- National Cancer Institute
- Moonshot Research and Development Program
- Cancer Moonshot