How accurate is ceftriaxone at predicting susceptibility of enterobacterales isolates to oral higher-generation cephalosporins?
The reliability of ceftriaxone for inferring susceptibility to higher-generation oral cephalosporins is unknown. Overall, ceftriaxone susceptibility predicted susceptibility to cefuroxime (89%), cefdinir (86%), cefpodoxime (90%), and cefixime (94%) based on disk diffusion results for 409 consecutive Enterobacterales bloodstream isolates from unique patients. Susceptibility percentages to the four oral cephalosporins ranged from 92% to 99% when limited to <i>Escherichia coli</i>, <i>Klebsiella pneumoniae, Klebsiella oxytoca, or Proteus mirabilis</i> isolates susceptible to ceftriaxone.
Authors
- Sara E. Cosgrove (ORCID: https://orcid.org/0000-0001-9458-4331)
- Pranita D. Tamma (ORCID: https://orcid.org/0000-0002-4143-6324)
- Tsigereda Tekle
- Kimberly C. Claeys (ORCID: https://orcid.org/0000-0001-6895-604X)
- Patricia J. Simner (ORCID: https://orcid.org/0000-0001-6134-151X)
- Anthony Harris (ORCID: https://orcid.org/0000-0003-4418-9944)
- Emily Jacobs
Institutions
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1128/aac.01387-24
- Citations
- 4
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- Patient-Centered Outcomes Research Institute
- Shionogi
- H2020 European Research Council