Novel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation
The use of radiopharmaceuticals for diagnostics in oncology allows for the detection of the disease at an early stage. Among diagnostic radionuclides, <sup>99m</sup>Tc is a promising isotope that has been used to create several drugs for clinical use. One of the most effective <sup>99m</sup>Tc chelators is 6-hydrazinylnicotinic acid (HYNIC), which, when combined with various vector molecules, can be used for targeted delivery of radionuclides to tumor tissues. At the same time, it is known that tetrapyrrole macrocycles are capable of selective accumulation in tumors, and thus can be used to target radiopharmaceuticals with <sup>99m</sup>Tc. In this work, the conjugate of natural chlorin and HYNIC was obtained, and preliminary preclinical studies were carried out on its radiocomplex with <sup>99m</sup>Tc.
Authors
- Nikita Suvorov (ORCID: https://orcid.org/0000-0002-2749-3656)
- Vitalina Bodenko (ORCID: https://orcid.org/0000-0001-5097-9737)
- Evgenii Plotnikov (ORCID: https://orcid.org/0000-0002-4374-6422)
- Е. В. Филоненко (ORCID: https://orcid.org/0000-0001-8506-7455)
- М. В. Белоусов (ORCID: https://orcid.org/0000-0002-2153-7945)
- Mikhail A. Grin (ORCID: https://orcid.org/0000-0002-4333-4516)
- Maxim Usachev
- Petr Ostroverkhov (ORCID: https://orcid.org/0000-0001-5778-4510)
- Ruslan Varvashenya (ORCID: https://orcid.org/0009-0002-4282-3198)
- Alexander Popov (ORCID: https://orcid.org/0000-0002-5622-5300)
- M. S. Larkina (ORCID: https://orcid.org/0000-0003-1176-2441)
- Gleb Yanovich
Institutions
- National Research Tomsk State University (RU)
- Siberian State Medical University (RU)
- Tomsk Polytechnic University (RU)
- MIREA - Russian Technological University (RU)
- P.A. Hertzen Moscow Oncology Research Institute (RU)
Publication Details
- Journal
- Molecules
- Published
- 2024-12-31
- DOI
- https://doi.org/10.3390/molecules30010117
- Citations
- 3
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- MIREA - Russian Technological University
- Ministry of Science and Higher Education of the Russian Federation