DNMT1-driven methylation of RORA facilitates esophageal squamous cell carcinoma progression under hypoxia through SLC2A3
DNMT1-driven methylation of RORA promotes ESCC progression largely through affecting SLC2A3 transcription and glycolysis. These findings turn RORA into potential target of anti-cancer therapeutic agents.
Authors
- Lei Xu (ORCID: https://orcid.org/0000-0002-0512-4796)
- Wenjian Yao (ORCID: https://orcid.org/0000-0003-4672-113X)
- Mingyu Feng
- Xiangbo Jia
- Yinghao Wang (ORCID: https://orcid.org/0000-0002-1928-0538)
- Yu Bai (ORCID: https://orcid.org/0000-0002-3318-3240)
- Sen Wu
- Linlin Shang
Institutions
- Henan University (CN)
- Capital Medical University (CN)
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s12967-024-05960-8
- Citations
- 7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Henan Provincial People's Hospital