Spatial transcriptomics reveals unique metabolic profile and key oncogenic regulators of cervical squamous cell carcinoma
Utilizing ST, scRNA-seq, and TCGA database, we examined the spatial metabolic profiles of CSCC tissues, including metabolism distribution, metabolic variations, and the relationship between metabolism and tumor differentiation degree. Additionally, potential cancer-promoting factors were proposed, offering a valuable foundation for the development of more effective treatment strategies for CSCC.
Authors
- Peipei Yao
- Xin Du (ORCID: https://orcid.org/0000-0002-6907-3609)
- Jiejie Liu (ORCID: https://orcid.org/0009-0006-5442-6471)
- Chao Shen (ORCID: https://orcid.org/0000-0001-5483-3348)
- Junbo Hu (ORCID: https://orcid.org/0000-0003-2606-8591)
- You Zhou (ORCID: https://orcid.org/0000-0002-7081-921X)
- Xing Liu (ORCID: https://orcid.org/0000-0003-1741-3437)
- Yu Chen (ORCID: https://orcid.org/0000-0002-8118-7262)
- Fei Chen (ORCID: https://orcid.org/0000-0003-2308-3649)
- Li Zhou (ORCID: https://orcid.org/0000-0002-6736-0057)
- Limin Zhou (ORCID: https://orcid.org/0000-0003-0296-8157)
Institutions
- Wuhan University (CN)
- Hubei Provincial Women and Children's Hospital (CN)
- Wuhan Children's Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University (CN)
- Cardiff University (GB)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s12967-024-06011-y
- Citations
- 6
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Natural Science Foundation of Hubei Province
- State Key Laboratory of Virology