Gasdermin D regulates the activation of EGFR in colorectal cancer
GSDMD-FL promotes CRC progression by inducing EGFR autophosphorylation at the Tyr1068 site, subsequently activating the downstream ERK1/2. Inhibition of GSDMD is a potential strategy for the treatment of colorectal cancer.
Authors
- Jiayu Shen (ORCID: https://orcid.org/0000-0001-8447-9378)
- Qindan Du
- Jiayao Chen (ORCID: https://orcid.org/0009-0000-1981-6382)
- Ying Li (ORCID: https://orcid.org/0000-0001-7370-1754)
- Huijun Liang (ORCID: https://orcid.org/0000-0001-7344-1489)
- Xiaoying Wang (ORCID: https://orcid.org/0000-0002-3855-4944)
Institutions
- Jiangnan University (CN)
- Soochow University (CN)
- Zhangjiagang First People's Hospital (CN)
- The Fifth People’s Hospital of Suzhou (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s12967-024-05984-0
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China