Resilience to Alzheimer's disease associates with alterations in perineuronal nets
Aggrecan levels are decreased in the frontal cortex of AD and resilient subjects. In resilient subjects, WFA+ PNNs are reduced around neuronal somata. In AD patients, PV neurons show disrupted WFA peridendritic staining and synaptic loss. Expression levels of PNN-degrading enzymes are higher in AD. Excitatory neurons bearing a PNN show low amounts of ptau.
Authors
- Dick F. Swaab (ORCID: https://orcid.org/0000-0002-9665-7845)
- Daniela Carulli (ORCID: https://orcid.org/0000-0003-1365-7063)
- Joost Verhaagen (ORCID: https://orcid.org/0000-0002-8341-1096)
- Luuk E. de Vries (ORCID: https://orcid.org/0009-0005-6133-1043)
- Anouck Bahnerth
Institutions
- Netherlands Institute for Neuroscience (NL)
- Royal Netherlands Academy of Arts and Sciences (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1002/alz.14504
- Citations
- 10
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 2.68