Cardiac fibroblast-specific expression of IL-37 confers the protective effects on fibrosis in diabetic cardiomyopathy mice by regulating SOCS3-STAT3 axis
Our findings indicate that IL-37 exerts its antifibrotic effect by promoting SOCS3-mediated JAK2-STAT3 inactivation and may be considered as a potential therapeutic agent for DCM.
Authors
- Bangwei Wu (ORCID: https://orcid.org/0000-0002-2765-4640)
- Xinping Luo (ORCID: https://orcid.org/0000-0001-9484-9467)
- Xiaoyan Shen (ORCID: https://orcid.org/0000-0001-8454-8185)
- Qingyu Huang (ORCID: https://orcid.org/0000-0002-5076-2084)
- Yiming Wang (ORCID: https://orcid.org/0000-0002-2493-0582)
- Jian H. Li (ORCID: https://orcid.org/0000-0003-0376-0702)
- Haiming Shi (ORCID: https://orcid.org/0000-0001-6733-7968)
- Bo Jin (ORCID: https://orcid.org/0000-0002-2911-7144)
- Yan You (ORCID: https://orcid.org/0009-0009-7917-0590)
- Tongqing Chen
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Journal of Geriatric Cardiology
- Published
- 2024-11-01
- DOI
- https://doi.org/10.26599/1671-5411.2024.11.004
- Citations
- 2
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China