LncRNA LUCAT1 offers protection against human coronary artery endothelial cellular oxidative stress injury through modulating hsa-miR-6776-5p/LRRC25 axis and activating autophagy flux
Our results delineated the dynamic disruption of the autophagy landscape during the progression of human coronary atherosclerosis and identified the lncRNA LUCAT1/hsa-miR-6776-5p/LRRC25 axis, uncovered through transcriptomic profiling, as a protective mechanism against endothelial cell injury through autophagy activation. Furthermore, we recognized p62, ATG7, lncRNA LUCAT1, and LRRC25 as dependable autophagy-related diagnostic biomarkers in circulating PBMCs, correlating with CAD severity. Collectively, Our findings furnish novel insights into the intricate autophagy landscape at various levels of coronary atherosclerosis and propose potential diagnostic biomarkers, and a theoretical foundation for managing CAD patients.
Authors
- Boyu Chi (ORCID: https://orcid.org/0000-0003-3147-9934)
- Qiaowei Jia
- En‐Zhi Jia (ORCID: https://orcid.org/0000-0003-1354-9855)
- Fenghui An (ORCID: https://orcid.org/0000-0002-6577-8847)
- Xiongkang Gan (ORCID: https://orcid.org/0000-0002-8245-6073)
- Yahong Fu (ORCID: https://orcid.org/0000-0002-4577-032X)
- Chengcheng Li (ORCID: https://orcid.org/0000-0002-4843-5404)
- Yanjun Wang (ORCID: https://orcid.org/0000-0002-1996-5465)
- Sheng Zhang (ORCID: https://orcid.org/0000-0001-8206-1007)
- Zhiyuan Chen (ORCID: https://orcid.org/0000-0001-6166-604X)
- Mengmeng Ren
- Shu He (ORCID: https://orcid.org/0000-0001-7914-5779)
- Xiumei Chen (ORCID: https://orcid.org/0000-0002-4174-1230)
- Hanxiao Zhou (ORCID: https://orcid.org/0000-0002-2052-0076)
- Hengjie Bie
- M Duan
- Xin Zhang (ORCID: https://orcid.org/0000-0003-0047-3134)
- Qian Zhang (ORCID: https://orcid.org/0000-0001-5975-9781)
Institutions
- Yili Friendship Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s12967-024-05966-2
- Citations
- 4
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nanjing Medical University
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Collaborative Innovation Center for Cardiovascular Disease Translational Medicine