Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations

Primary CMEs present allele-specific differential interaction patterns with neighbouring genes and regulatory elements. The role of the identified cis-regulatory regions in the molecular mechanism underlying the origin and maintenance of CME requires further investigation.

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Publication Details

Journal
Clinical Epigenetics
Published
2024-12-31
DOI
https://doi.org/10.1186/s13148-024-01770-3
Primary Topic
Genetic factors in colorectal cancer
Type
article
Field-Weighted Citation Impact
0.00

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article

Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations

Mireia Ramos-Rodríguez, Helena Raurell, Gabriel Capellá, Gi Won Shin et al.
Clinical Epigenetics
Genetic factors in colorectal cancer
article

Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations

Mireia Ramos-Rodríguez, Helena Raurell, Gabriel Capellá, Gi Won Shin, Paula Climent‐Cantó, Beatriz Pérez-González, Elisabet Munté, Fátima Marín, Hanlee P. Ji, Marc Subirana-Granés, Covadonga Vara, Estela Dámaso, Marta Pineda, Lorenzo Pasquali, Megan P. Hitchins, José Luís Soto, Ángel Alonso
article en

Abstract

Primary CMEs present allele-specific differential interaction patterns with neighbouring genes and regulatory elements. The role of the identified cis-regulatory regions in the molecular mechanism underlying the origin and maintenance of CME requires further investigation.

Clinical EpigeneticsVol. 16(1)
Cedars-Sinai Medical Center (US), Universitat Pompeu Fabra (ES), Universidad Pública de Navarra (UPNA) (ES), Instituto de Salud Carlos III (ES), Institut d'Investigació Biomédica de Bellvitge (ES), Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES), Institut Català d'Oncologia (ES), Navarrabiomed (ES), Centro de Investigación Biomédica en Red de Cáncer (ES), Stanford University (US)
Eli Lilly and Company, Centres de Recerca de Catalunya, European Foundation for the Study of Diabetes, Generalitat de Catalunya, Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación, National Cancer Institute
Peace, Justice and strong institutions
Openalex Percentile: Top 60%
Genetic factors in colorectal cancer
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