Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations
Primary CMEs present allele-specific differential interaction patterns with neighbouring genes and regulatory elements. The role of the identified cis-regulatory regions in the molecular mechanism underlying the origin and maintenance of CME requires further investigation.
Authors
- Mireia Ramos-Rodríguez (ORCID: https://orcid.org/0000-0001-8083-2445)
- Helena Raurell
- Gabriel Capellá (ORCID: https://orcid.org/0000-0002-4669-7320)
- Gi Won Shin (ORCID: https://orcid.org/0000-0002-1865-5019)
- Paula Climent‐Cantó (ORCID: https://orcid.org/0000-0003-3554-5804)
- Beatriz Pérez-González (ORCID: https://orcid.org/0000-0001-9849-5176)
- Elisabet Munté (ORCID: https://orcid.org/0000-0001-8396-8284)
- Fátima Marín (ORCID: https://orcid.org/0000-0003-3534-0091)
- Hanlee P. Ji (ORCID: https://orcid.org/0000-0003-3772-3424)
- Marc Subirana-Granés (ORCID: https://orcid.org/0000-0003-3934-839X)
- Covadonga Vara (ORCID: https://orcid.org/0000-0002-8264-9262)
- Estela Dámaso (ORCID: https://orcid.org/0000-0002-9650-7791)
- Marta Pineda (ORCID: https://orcid.org/0000-0002-5403-5845)
- Lorenzo Pasquali (ORCID: https://orcid.org/0000-0003-2423-1826)
- Megan P. Hitchins (ORCID: https://orcid.org/0000-0002-3603-2309)
- José Luís Soto (ORCID: https://orcid.org/0000-0003-0234-9188)
- Ángel Alonso (ORCID: https://orcid.org/0000-0001-5111-310X)
Institutions
- Cedars-Sinai Medical Center (US)
- Universitat Pompeu Fabra (ES)
- Universidad Pública de Navarra (UPNA) (ES)
- Instituto de Salud Carlos III (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Institut Català d'Oncologia (ES)
- Navarrabiomed (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Stanford University (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1186/s13148-024-01770-3
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Centres de Recerca de Catalunya
- European Foundation for the Study of Diabetes
- Generalitat de Catalunya
- Ministerio de Ciencia e Innovación
- Agencia Estatal de Investigación
- National Cancer Institute