ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization
ALKBH5 promotes M2 macrophage polarization and alleviates lower extremity atherosclerosis by regulating the demethylation of ITGB1. A deeper understanding of this process not only helps elucidate the molecular mechanisms of atherosclerosis but also provides possibilities for the development of new therapeutic strategies.
Authors
- Ran Lu (ORCID: https://orcid.org/0000-0001-9500-3500)
- Zhiqiang Guan (ORCID: https://orcid.org/0000-0002-6053-2717)
- Xiaogao Wang
- Chao Xu (ORCID: https://orcid.org/0000-0003-2194-0862)
Institutions
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e41495
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.94