Involvement of the astroglial glutamate–glutamine cycle in the analgesic effects of electroacupuncture in a rat model of chronic neuropathic pain
Repeated EA administration inhibited CCI-induced chronic neuropathic pain in rats, corresponding to a reversal of decreased expression of GLAST and GLT-1, which may have accelerated the clearance of Glu and thereby reduced its concentration. Regulation of the astroglial glutamate-glutamine cycle is a potential target of EA.
Authors
- Jianliang Zhang (ORCID: https://orcid.org/0000-0003-2494-0040)
- Peijing Rong (ORCID: https://orcid.org/0000-0002-7288-2319)
- Junying Wang (ORCID: https://orcid.org/0000-0002-7962-6641)
- Haohan Zhu (ORCID: https://orcid.org/0009-0009-4009-3137)
- Jin-Ling Zhang
- Xingke Song (ORCID: https://orcid.org/0000-0002-1958-1832)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Acupuncture in Medicine
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1177/09645284241309952
- Citations
- 4
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Natural Science Foundation of Beijing Municipality