The study of Transdermal Permeation of Helianthus tuberosus L. extracts in Franz Diffusion Cell

Helianthus tuberosus L. (H.tuberosus L.), commonly known as the Jerusalem artichoke, is a traditional food ingredient in Korea.It has been extensively studied for its various health-promoting activities, including the modulation of blood glucose levels and improvement of skin hydration.The main bioactive compound in the H. tuberosus L. extract is inulin, a natural polysaccharide acting as a potential functional ingredient for cosmetic formulations.In this study, we aimed to enhance the dermal permeability of inulin via the strategic incorporation of surfactants into the H. tuberosus L. extract.Skin permeability of inulin was analyzed in vitro using the Franz diffusion cell system with the Strat-M membrane, an artificial skin model designed to mimic the barrier function of human skin.BT-12 (4.22 0.37 mg/mL) -The treated group exhibited significantly higher inulin permeability over 24 h than the control group (1.26 0.22 mg/mL).Additionally, inulin permeability was evaluated by measuring the Flux and Kp values.Experimental group 1 treated with BT-12 (3.24 3.22 mg/h/cm and 32.38 32.19 cm/h*10-3, respectively) exhibited higher Flux and Kp values than the control group (0.78 0.41 mg/h/cm and 7.78 4.06 cm/h*10-3, respectively).Overall, this study outlined a protocol to enhance the dermal permeability of inulin in the H. tuberosus L. extract, providing a new avenue for its application in topical cosmetic formulations.