Single-cell and spatial transcriptomics reveal SPP1-CD44 signaling drives primary resistance to immune checkpoint inhibitors in RCC
Our findings reveal a potential mechanism by which SPP1-CD44 signaling mediates tumor-immune cell interactions leading to ICI resistance, providing a theoretical basis for targeting and disrupting this signaling to overcome primary resistance in RCC.
Authors
- Xing Bi
- Fuzhong Liu (ORCID: https://orcid.org/0009-0007-7166-9157)
- Shuai Yuan (ORCID: https://orcid.org/0000-0003-4037-3429)
- Junfeng Zhang (ORCID: https://orcid.org/0000-0002-3511-8055)
- Qingyan Peng
- Kailing Li (ORCID: https://orcid.org/0000-0002-2327-0914)
- Ting Pan (ORCID: https://orcid.org/0000-0002-7106-7312)
- Hongbo Chen (ORCID: https://orcid.org/0000-0002-0954-5600)
- Peng Chen (ORCID: https://orcid.org/0000-0001-8462-2875)
- Jin Fan (ORCID: https://orcid.org/0000-0001-8293-2028)
- Sihai Tan
- Wei Jiang (ORCID: https://orcid.org/0000-0002-9027-4974)
Institutions
- Xinjiang Medical University (CN)
- Tumor Hospital of Xinjiang Medical University (CN)
- The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1186/s12967-024-06018-5
- Citations
- 23
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 6.50
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Xinjiang