Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naïve adults
Vaccination of hookworm-naïve adults with Na-GST-1/Alhydrogel plus CpG 10104 was safe and minimally reactogenic. Addition of CpG 10104 to Na-GST-1/Alhydrogel resulted in significant improvement in IgG responses against the vaccine antigen. These promising results have led to inclusion of the CpG 10104 formulation of Na-GST-1/Alhydrogel in a Phase 2 proof-of-concept controlled human infection trial.
Authors
- Lara Hoeweler
- Maria Bova (ORCID: https://orcid.org/0000-0002-7655-0696)
- David Joseph Diemert (ORCID: https://orcid.org/0000-0002-2789-0512)
- Jeffrey Bethony (ORCID: https://orcid.org/0000-0002-7901-2113)
- María Elena Bottazzi (ORCID: https://orcid.org/0000-0002-8429-0476)
- Doreen Campbell
- Maria Zumer
- Peter J. Hotez (ORCID: https://orcid.org/0000-0001-8770-1042)
- Guangzhao Li (ORCID: https://orcid.org/0000-0002-5007-8338)
- Elissa Malkin
- Christina Gibbs-Tewary
Institutions
- Milken Institute (US)
- Baylor College of Medicine (US)
- George Washington University (US)
- Texas Children's Hospital (US)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1371/journal.pntd.0012788
- Citations
- 3
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Ministry of Foreign Affairs