Therapeutic Effect of Green-Lipped Mussel Oil on Pain and Functional Disability in Dogs with Clinical Osteoarthritis

This study aimed to assess the therapeutic effects of green-lipped mussel oil complex (GLMOC) on canine osteoarthritis (OA) and effects of dose and OA severity on treatment efficacy.Fifteen dogs were recruited and grouped into two based on OA severity.They received the recommended GLMOC dose for the first 4 weeks and half for the following 2 weeks, which was followed by a 2-week withdrawal.The outcomes included the Canine Brief Pain Inventory (CBPI) score, orthopaedic assessment score (OAS), and peak vertical force (PVF).The CBPI score, OAS, and PVF significantly improved at week 4.The treatment success rate was 40%.The improvements persisted during the reduction and withdrawal phases but their significance reduced.The PVF (week 4), CBPI score (weeks 4 and 6), and OAS (weeks 4, 6, and 8) significantly improved for the dogs with mild/moderate OA.The OAS significantly improved for severe OA only at week 4. GLMOC treatment provided significant pain relief and functional improvement for OA over 4 weeks without adverse effects.Optimal outcomes are expected in patients with mild or moderate OA treated with consistent medications.