Enhanced safety and efficacy profile of CD40 antibody upon encapsulation in pHe-triggered membrane-adhesive nanoliposomes
pHTANL-CD40a is more effective than free CD40a in anti-tumor activity, especially in altering the TME immune landscape for a potential therapeutic benefit in combination with immunotherapy.
Authors
- Duy Luong
- Seong Ho Kim (ORCID: https://orcid.org/0000-0002-2371-7042)
- Arun K. Iyer (ORCID: https://orcid.org/0000-0002-4428-0222)
- Navnath S. Gavande (ORCID: https://orcid.org/0000-0002-2413-0235)
- Lisa Polin (ORCID: https://orcid.org/0000-0002-9189-055X)
- Samaresh Sau (ORCID: https://orcid.org/0000-0002-4364-5875)
- Yubin Ge (ORCID: https://orcid.org/0000-0002-8748-716X)
- Prahlad Parajuli (ORCID: https://orcid.org/0000-0002-3757-3246)
- Salma Althobaiti
Institutions
- Eugene Applebaum College of Pharmacy and Health Sciences (US)
- Wayne State University (US)
- The Barbara Ann Karmanos Cancer Institute (US)
Publication Details
- Journal
- Nanomedicine
- Published
- 2024-12-29
- DOI
- https://doi.org/10.1080/17435889.2024.2446008
- Citations
- 3
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.52
Funders
- U.S. Department of Defense
- Wayne State University
- Barbara Ann Karmanos Cancer Institute
- DMC Foundation
- National Institutes of Health
- Congressionally Directed Medical Research Programs