Yiqi Huayu Jiedu formula inhibits JAK2/STAT3-mediated partial EMT in treating chronic atrophic gastritis
The YQHYJD formula treats CAG by inhibiting the JAK2/STAT3 -mediated pEMT, thereby suppressing the gastric "inflammation-cancer" transformation. This study provides mechanistic insights into the efficacy of YQHYJD in CAG treatment and suggests new therapeutic strategies for preventing gastric cancer development.
Authors
- Guihua He
- Zhenhao Ye
- Weifeng Yu (ORCID: https://orcid.org/0000-0003-1979-6304)
- Zishao Zhong
- Xifei Guan
- Suiping Huang (ORCID: https://orcid.org/0000-0001-9484-3487)
- Wang Zhang (ORCID: https://orcid.org/0000-0002-4558-3487)
- Hudan Pan
- Shuni Chen
- Haiyan Zhang (ORCID: https://orcid.org/0009-0005-6955-564X)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1016/j.phymed.2024.156356
- Citations
- 8
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.58