Expert consensus and current landscape of NUT carcinoma: A comprehensive strategy from diagnosis to treatment
Nuclear protein of the testis (NUT) carcinoma is a rare and highly aggressive malignancy characterized by the rearrangement of the NUT midline carcinoma family member 1 (NUTM1) gene. Nevertheless, standardized strategies for its diagnosis and treatment remain unavailable, underscoring the need for expert consensus. To address this gap, we conducted a systematic review to gather comprehensive information on NUT carcinoma from five databases: PubMed, Web of Science, Embase, Cochrane Library, and Ovid Medline. This expert consensus was collaboratively developed by a team of international multidisciplinary experts, in partnership with the NUT Carcinoma Diagnosis Working Group of the Chinese Anti-Cancer Association’s Oncogene Diagnosis Professional Committee. This working group comprises medical oncologists, radiation oncologists, surgical oncologists, pathologists, nurses, molecular biologists, statisticians, and bioinformatics specialists. A systematic review, based on data from 526 patients across 199 articles, was conducted to comprehensively explore various characteristics, including demographic features (e.g., patient gender, distribution regions, and age), tumor-node-metastasis (TNM) classification stage, clinical symptoms, tumor size, metastatic patterns, immunohistochemical (IHC) findings, treatment modalities, prognosis-related information, and NUTM1 fusion partners. We have developed an expert consensus on diagnosing and treating NUT carcinoma using a multidisciplinary approach. The guideline provides eight recommendations, addressing epidemiological characteristics, clinical and imaging manifestations, pathological findings, IHC features, molecular mechanisms and subtypes, prognosis, diagnosis, and treatment strategies for NUT carcinoma. Furthermore, an international platform has been established to disseminate NUT carcinoma knowledge and patient recruitment, providing patients and healthcare providers access to NUT carcinoma-related information and updates on clinical trial recruitment.
Authors
- Hongxue Meng (ORCID: https://orcid.org/0000-0002-1831-2737)
- Longxiang Wu
- Dawei Wu (ORCID: https://orcid.org/0000-0003-4888-3255)
- Axel H. Schönthal (ORCID: https://orcid.org/0000-0003-0662-5653)
- Zihuan Yang (ORCID: https://orcid.org/0000-0002-0244-3214)
- Paolo Boffano (ORCID: https://orcid.org/0000-0002-0782-9933)
- Jinliang Xing (ORCID: https://orcid.org/0000-0002-7010-1822)
- Yuanzhi Lü
- Guobin Fu (ORCID: https://orcid.org/0000-0003-0893-7714)
- Kalevi Kairemo (ORCID: https://orcid.org/0000-0002-5194-746X)
- Zhuomiao Ye (ORCID: https://orcid.org/0000-0003-2983-5944)
- Zhiyong Mao (ORCID: https://orcid.org/0000-0002-5298-1918)
- Jianchun Duan (ORCID: https://orcid.org/0000-0003-3300-1707)
- Pierfrancesco Franco (ORCID: https://orcid.org/0000-0003-2276-0687)
- Lang He (ORCID: https://orcid.org/0009-0003-8156-2768)
- Xifeng Pan (ORCID: https://orcid.org/0000-0002-1462-6501)
- Wantao Chen (ORCID: https://orcid.org/0000-0002-9307-162X)
- Mingzhu Yin (ORCID: https://orcid.org/0000-0002-6964-7131)
- Xinpei Deng (ORCID: https://orcid.org/0000-0001-9973-2559)
- Ruiqin Han (ORCID: https://orcid.org/0000-0001-6811-7019)
- Yanfang Jiang (ORCID: https://orcid.org/0000-0002-2478-1521)
- Shaoquan Zheng (ORCID: https://orcid.org/0000-0003-1912-0216)
- Xin Li (ORCID: https://orcid.org/0000-0003-0003-8554)
- José Manuel Lopes (ORCID: https://orcid.org/0000-0001-8597-3474)
- Chengzhi Zhou (ORCID: https://orcid.org/0000-0003-0029-6879)
- Zhimin Bian
- Helmut Popper (ORCID: https://orcid.org/0000-0003-4970-1265)
- Jianfu Zhao (ORCID: https://orcid.org/0000-0001-6130-7266)
- Bing Wei (ORCID: https://orcid.org/0000-0001-9340-1409)
- Qingwei Meng
- Song Duan
- Hongle Li (ORCID: https://orcid.org/0000-0001-6428-9091)
- Evan T. Keller (ORCID: https://orcid.org/0000-0002-7592-7535)
- Di Qu (ORCID: https://orcid.org/0000-0002-1801-0296)
- Weilin Jin (ORCID: https://orcid.org/0000-0001-8011-2405)
- Angel Moya
- Hongyang Lu
- Jinhai Deng (ORCID: https://orcid.org/0000-0002-2899-5332)
- Qin Zhou (ORCID: https://orcid.org/0000-0003-3559-2344)
- Mikael S. Lindström (ORCID: https://orcid.org/0000-0003-1148-8497)
- Аlexander А. Shtil (ORCID: https://orcid.org/0000-0001-6469-0221)
- Vishal G. Shelat (ORCID: https://orcid.org/0000-0003-3988-8142)
- Wenping Ma (ORCID: https://orcid.org/0000-0002-1564-4584)
- Guodong Zhu
- Chunming Ding (ORCID: https://orcid.org/0000-0002-2063-5594)
- Nejat Düzgüneş (ORCID: https://orcid.org/0000-0001-6159-1391)
- Nong Yang (ORCID: https://orcid.org/0000-0003-0997-3645)
- Zheng Qing Zhao (ORCID: https://orcid.org/0000-0002-5536-0439)
- Athanasios G. Papavassiliou (ORCID: https://orcid.org/0000-0001-5803-4527)
- Steven T. Brower
- Fei Xie (ORCID: https://orcid.org/0000-0003-0947-6438)
- Yi Shi (ORCID: https://orcid.org/0000-0002-4322-8174)
- Songtao Yu
- Xuening Li (ORCID: https://orcid.org/0009-0002-5194-8021)
- Hifzur R. Siddique (ORCID: https://orcid.org/0000-0001-8736-0487)
- Hongmei Zhang (ORCID: https://orcid.org/0000-0002-3991-3750)
- Yayi He (ORCID: https://orcid.org/0000-0002-2820-9119)
- Chao Li (ORCID: https://orcid.org/0000-0002-2445-7545)
- Yu Li (ORCID: https://orcid.org/0000-0002-8828-7020)
- Yan Liu (ORCID: https://orcid.org/0000-0002-5837-4908)
- Yanqing Liu (ORCID: https://orcid.org/0000-0001-6812-2811)
- Jun Li (ORCID: https://orcid.org/0000-0002-8664-4813)
- Heng Zhang (ORCID: https://orcid.org/0000-0002-8912-1655)
- Xiaodong Liu (ORCID: https://orcid.org/0000-0002-6879-990X)
- Yongsheng Li
- Yang Li (ORCID: https://orcid.org/0000-0002-2230-2611)
- Rui Chen (ORCID: https://orcid.org/0000-0002-4387-9735)
- Zhe Wang (ORCID: https://orcid.org/0000-0001-9117-7917)
- Qiming Wang (ORCID: https://orcid.org/0000-0002-9386-5091)
- Lidong Wang (ORCID: https://orcid.org/0000-0002-6900-7433)
- Hao Ling (ORCID: https://orcid.org/0000-0003-3729-9846)
- Wenbin Li (ORCID: https://orcid.org/0009-0003-0225-6384)
- Lifeng Li (ORCID: https://orcid.org/0000-0002-7492-4017)
- Dan Yang (ORCID: https://orcid.org/0000-0001-5959-1202)
- Shubin Wang (ORCID: https://orcid.org/0000-0002-0657-297X)
- Chao Deng (ORCID: https://orcid.org/0000-0002-3612-5249)
- Zengjun Liu (ORCID: https://orcid.org/0000-0003-3610-1586)
- Xiangwen Luo
- Lijun Xu (ORCID: https://orcid.org/0000-0003-0455-410X)
- Yan Qin (ORCID: https://orcid.org/0000-0002-0900-883X)
- Yang Song (ORCID: https://orcid.org/0000-0002-4492-9116)
- Yubo Yan
- Min Tang (ORCID: https://orcid.org/0000-0002-6883-1770)
- Lixin Qiu (ORCID: https://orcid.org/0000-0003-3451-0191)
- Zhi Yi (ORCID: https://orcid.org/0000-0002-8924-6335)
- Min Peng (ORCID: https://orcid.org/0000-0001-6648-945X)
- Minghui Zhang (ORCID: https://orcid.org/0000-0001-8850-9642)
- Junmei Jia
- Chong Bai (ORCID: https://orcid.org/0000-0003-2039-5751)
- Mohamed Kamal
- Qingxia Li (ORCID: https://orcid.org/0000-0001-9934-7837)
- Rensheng Lai
- Ye Guo (ORCID: https://orcid.org/0009-0006-2409-041X)
- Anjie Min
- Xiaotong Hu
- Mengyuan Wang (ORCID: https://orcid.org/0009-0005-8932-5518)
- H.Q. Su (ORCID: https://orcid.org/0009-0008-5930-8196)
- Lijuan Zhang (ORCID: https://orcid.org/0000-0002-9076-1000)
- Lichao Guo (ORCID: https://orcid.org/0000-0003-1733-1802)
Publication Details
- Journal
- Tumor Discovery
- Published
- 2024-12-24
- DOI
- https://doi.org/10.36922/td.4904
- Citations
- 4
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Centre Scientifique et Technique du Bâtiment