Biocompatible synthesis of macrocyclic thiazole peptides from chiral α-amino nitriles
Macrocyclic peptides containing a thiazole heterocycle exhibit fascinating properties in natural products and future therapeutics. We report a biocompatible macrocyclisation approach facilitated by an N-terminal cysteine and C-terminal nitriles. The use of various chiral α-amino nitriles enables the incorporation of diverse hydrophobic side chains adjacent to the thiazole motif.
Authors
- Christoph Nitsche
- Michael G. Gardiner (ORCID: https://orcid.org/0000-0001-6373-4253)
- Junming He (ORCID: https://orcid.org/0009-0002-9525-278X)
- Minghao Shang (ORCID: https://orcid.org/0000-0003-4754-1245)
Institutions
- Australian National University (AU)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1039/d4ob01989j
- Citations
- 1
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Australian Research Council