Reappraisal of the fundamental mechanisms of the sHA14-1 molecule as a Bcl-2/Bcl-XL ligand in the context of anticancer therapy: A cell biological study
Our results suggested that sHA14-1 plays a multifunctional role, involving both mitochondria and the endoplasmic reticulum. Its actions are more complex than its originally intended role in targeting anti-apoptotic Bcl-2 family members, which may complicate its potential application as an anticancer therapy.
Authors
- Philippe Diolez (ORCID: https://orcid.org/0000-0002-7548-2070)
- Pauline Andreu
- Delphine Fradin (ORCID: https://orcid.org/0000-0001-6231-2649)
- Patrice X. Petit (ORCID: https://orcid.org/0000-0002-5038-9101)
- Aoula Moustapha (ORCID: https://orcid.org/0009-0008-5506-7946)
- François Gonzalvez
- J.P. Tissier
Institutions
- Inserm (FR)
- Electrophysiology and Heart Modeling Institute (FR)
- National Institute of Health (AM)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- Institut Cochin (FR)
- Computer Science Laboratory of Lille (FR)
- SPPIN - Saints-Pères Paris Institute for Neurosciences (FR)
Publication Details
- Journal
- Journal of Biological Methods
- Published
- 2024-12-30
- DOI
- https://doi.org/10.14440/jbm.2024.0055
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique