Enrichment of Cancer‐Associated Fibroblasts, Macrophages, and Up‐Regulated <scp>TNF</scp> ‐α Signaling in the Tumor Microenvironment of <scp>CMS4</scp> Colorectal Peritoneal Metastasis
Tumor samples from different metastatic sites exhibited a broadly similar TME in terms of immune cell composition, with some intriguing differences. Targeting CAF-associated pathways, macrophages, and TNF-α signaling through NR4A could represent potential novel therapeutic approaches in CMS4 PM.
Authors
- Kjersti Flatmark (ORCID: https://orcid.org/0000-0001-7409-0780)
- Chakravarthi Kanduri (ORCID: https://orcid.org/0000-0002-4783-9060)
- Susanne Lorenz (ORCID: https://orcid.org/0000-0001-9254-968X)
- Christin Lund‐Andersen (ORCID: https://orcid.org/0000-0002-7277-6612)
- Eirik Høye (ORCID: https://orcid.org/0000-0002-9782-756X)
- Vegar Johansen Dagenborg (ORCID: https://orcid.org/0000-0002-9851-1866)
- Stein Gunnar Larsen (ORCID: https://orcid.org/0000-0002-9831-1995)
- Åsmund Avdem Fretland (ORCID: https://orcid.org/0000-0002-0945-5189)
- Annette Torgunrud (ORCID: https://orcid.org/0000-0001-5751-9549)
- Bjørn Edwin (ORCID: https://orcid.org/0000-0002-3137-6225)
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1002/cam4.70521
- Citations
- 4
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Kreftforeningen
- Helse Sør-Øst RHF