Differential Response to Cisplatin between Co-cultured Cells and Pure Cultured Cells Based on Single-cell RNA Sequencing of Three-dimensional-cultured Breast Cancer Cells
scRNA-seq analysis revealed that the response of MCF-7 cells to cisplatin in the co-culture model was lower than that in the mono-culture model. Therefore, the three-dimensional cell co-culture model can be applied to tumor research to better mimic the pathophysiological environment <i>in vivo</i> and can be a well-modified research method.
Authors
- Guolin Ye (ORCID: https://orcid.org/0000-0003-3592-4265)
- Aiguo Wu (ORCID: https://orcid.org/0000-0001-7200-8923)
- Kairong Lin (ORCID: https://orcid.org/0000-0001-6533-3357)
- Peixian Chen (ORCID: https://orcid.org/0000-0001-9268-3854)
- Wei Luo (ORCID: https://orcid.org/0000-0002-8845-903X)
- Shu‐Qing Yang (ORCID: https://orcid.org/0000-0001-9468-8069)
- Guangyu Yao (ORCID: https://orcid.org/0000-0001-7389-0401)
- Dan Zhou (ORCID: https://orcid.org/0009-0005-6925-1232)
- Wei Li (ORCID: https://orcid.org/0000-0001-8297-130X)
- Tiancheng He (ORCID: https://orcid.org/0000-0003-3543-5701)
- Xiaofan Mao
- Huiqi Huang
Institutions
- Nanfang Hospital (CN)
- First People's Hospital of Foshan (CN)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-11-29
- DOI
- https://doi.org/10.31083/j.fbl2912406
- Citations
- 1
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.28