Intratumoural CD8+ CXCR5+ follicular cytotoxic T cells have prognostic value and are associated with CD19+ CD38+ B cells and tertiary lymphoid structures in colorectal cancer
The prognostic prediction model has good predictive value. In MSS CRC, T<sub>FC</sub> cells function mostly in T cell activation and the cell cycle and have low expression of immune checkpoint molecules, which may influence the effectiveness of ICB therapy. T<sub>FC</sub> cells may regulate antitumor function by regulating CD19<sup>+</sup> CD38<sup>+</sup> B cells and TLSs.
Authors
- Ting Xiao (ORCID: https://orcid.org/0000-0002-9000-1909)
- G Wang
- Fei Huang (ORCID: https://orcid.org/0000-0003-3263-0675)
- Fangze Wei
- Fu Zhao (ORCID: https://orcid.org/0000-0002-5286-5650)
- Jing Wang (ORCID: https://orcid.org/0000-0002-5398-0802)
- Xiaotian Xu (ORCID: https://orcid.org/0000-0003-3862-1630)
- Shengkai Huang (ORCID: https://orcid.org/0000-0001-6702-243X)
- Wei Cui
- Baojun Wei
- Shan Mei (ORCID: https://orcid.org/0000-0003-1231-2055)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1007/s00262-024-03887-z
- Citations
- 8
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 1.92