Identification and Characterisation of Potential Targets for N6-methyladenosine (m6A) Modification during Intervertebral Disc Degeneration
Human IDD samples exhibited a distinct m6A modification pattern that allowed associated genes and pathways to be identified. These genes had functions such as "nuclear factor kappa-B (NF-κB) binding" and "extracellular matrix components", which are crucial for IDD pathogenesis. <i>ANXA2</i> showed increased m6A modification in IDD, while <i>SLC3A2</i> and <i>PBX3</i> showed decreased m6A methylation. The results of this study offer novel insights for the prevention and treatment of IDD.
Authors
- Jianlin Shen (ORCID: https://orcid.org/0000-0002-5853-094X)
- Qinglin Peng (ORCID: https://orcid.org/0000-0002-1271-1729)
- Yujian Lan
- Ziyu Ji
- Huan Liu (ORCID: https://orcid.org/0000-0002-5519-7336)
- Qiang Zhang (ORCID: https://orcid.org/0000-0002-7666-2188)
- Yanjiao Wu
Institutions
- Southwest Medical University (CN)
- The First People's Hospital of Shunde (CN)
- Southern Medical University (CN)
- Putian University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-11-28
- DOI
- https://doi.org/10.31083/j.fbl2912405
- Citations
- 1
- Primary Topic
- Cardiac Structural Anomalies and Repair
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Natural Science Foundation of China