Effects of Extracellular Matrix Changes Induced by a High-Fat Diet on Gallbladder Smooth Muscle Dysfunction
Our findings reveal a mechanism by which an HFD alters the ECM composition of the gallbladder muscle, activating the integrin/PI3K-Akt/MMP signaling pathway, thereby impacting GSMC phenotype and contractility. These insights enhance the understanding of gallstone formation mechanism and provide potential therapeutic targets to treat gallbladder dysfunction.
Authors
- Jinlong Hu (ORCID: https://orcid.org/0000-0002-9898-8103)
- Bing Shen (ORCID: https://orcid.org/0000-0001-7263-4748)
- Junbin Peng
- Chao Zhang (ORCID: https://orcid.org/0000-0002-0778-4608)
- Xingguo Zhong
- Feifei Wu
- Kehan Zhong
- Chong Zhang (ORCID: https://orcid.org/0009-0002-4785-4276)
- Weicheng Gao
Institutions
- Macau University of Science and Technology (MO)
- Bengbu Medical College (CN)
- Anhui University of Science and Technology (CN)
- Anhui Medical University (CN)
- Anhui Provincial Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Qiqihar Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-11-27
- DOI
- https://doi.org/10.31083/j.fbl2912401
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.33