Dexmedetomidine Mitigates Acute Lung Injury by Enhancing M2 Macrophage Polarization and Inhibiting RAGE/Caspase-11-Mediated Pyroptosis
Dex treatment can inhibit inflammation and reduce lung injury caused by CLP. It could be associated with mediating M1 and M2 polarization and suppressing RAGE/Caspase-11-depended pyroptosis.
Authors
- Liuyang Wang
- Shihui Lin (ORCID: https://orcid.org/0000-0001-6018-2107)
- Yi Zhao (ORCID: https://orcid.org/0000-0002-5254-8671)
- Kefeng Li (ORCID: https://orcid.org/0000-0002-7233-4347)
- Gang Kuang
- Ke Xie
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-12-03
- DOI
- https://doi.org/10.31083/j.fbl2912409
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Natural Science Foundation of Chongqing