Activated/Cycling Treg Deficiency and Mitochondrial Alterations in Immunological Non-Responders to Antiretroviral Therapy
The complex Treg dysregulation in immunological non-responders involves quantitative and functional alterations, including a Treg deficiency within activated/cycling naive and central memory CD4<sup>+</sup> T-cells, impaired mitochondrial fitness of activated/cycling memory Tregs, and functional disorders of the parent conventional T-lymphocytes. These findings underscore the need for a nuanced understanding of Treg dynamics in suboptimal CD4<sup>+</sup> T-cell reconstitution during HIV-infection.
Authors
- Souheil‐Antoine Younes (ORCID: https://orcid.org/0000-0003-2186-7140)
- K. V. Shmagel (ORCID: https://orcid.org/0000-0001-6355-6178)
- Е. В. Сайдакова (ORCID: https://orcid.org/0000-0002-4342-5362)
- L. B. Korolevskaya (ORCID: https://orcid.org/0000-0001-9840-7578)
- В. В. Власова (ORCID: https://orcid.org/0000-0002-1656-7277)
Institutions
- Perm State University (RU)
- Emory University (US)
- Institute of Ecology and Genetics of Microorganisms (RU)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-12-25
- DOI
- https://doi.org/10.31083/j.fbl2912429
- Citations
- 1
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.69
Funders
- Case Western Reserve University
- Ural Branch, Russian Academy of Sciences