Effect of 2-Aminoethoxydiphenyl Borate on the State of Skeletal Muscles in Dystrophin-Deficient mdx Mice
APB is able to improve the phenotype in <i>mdx</i> mouse DMD model. However, the effect of APB is quite limited, which may be due to its multitargeting of Ca<sup>2+</sup> channels in the membranes of muscle fibers and intracellular organelles, differentially expressed in DMD.
Authors
- Eugeny Yu. Talanov (ORCID: https://orcid.org/0000-0001-6227-7409)
- Anastasia D. Igoshkina
- I. B. Mikheeva (ORCID: https://orcid.org/0000-0001-8054-0477)
- Mikhail V. Dubinin (ORCID: https://orcid.org/0000-0002-7453-3390)
- Konstantin N. Belosludtsev (ORCID: https://orcid.org/0000-0001-5392-7035)
- Alena A. Cherepanova (ORCID: https://orcid.org/0009-0001-3290-6603)
- Anastasia E. Stepanova (ORCID: https://orcid.org/0000-0003-2573-4847)
Institutions
- Mari State University (RU)
- Institute of Theoretical and Experimental Biophysics (RU)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-12-25
- DOI
- https://doi.org/10.31083/j.fbl2912428
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Russian Science Foundation
- Lomonosov Moscow State University