Combined Use of Intranasal Methylprednisolone and Allopregnanolone: Revisiting Anti-inflammatory and Remyelinating Treatment in a Murine Model of Multiple Sclerosis
ALLO treatment mainly maintain the integrity of the spinal cord tissue and the presence of myelin without affecting NI and the clinical outcome. AhR could be involved in the effect observed in both, MP and ALLO treatments. These results will help in the development of a more efficient therapy for MS patients.
Authors
- Gladis Fragoso (ORCID: https://orcid.org/0000-0003-3885-1858)
- Edda Sciutto (ORCID: https://orcid.org/0000-0001-5608-5355)
- Mónica Torres-Ramos (ORCID: https://orcid.org/0000-0002-8900-4037)
- Rodrigo González-Flores (ORCID: https://orcid.org/0000-0002-4171-0792)
- Ivan Nicolás Pérez‐Osorio (ORCID: https://orcid.org/0000-0002-5946-5318)
- Alejandro Espinosa (ORCID: https://orcid.org/0000-0002-9455-4500)
- Hugo O. Besedovsky (ORCID: https://orcid.org/0000-0001-7149-0471)
- Camila Álvarez-Gutiérrez
Institutions
- Philipps University of Marburg (DE)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-12-18
- DOI
- https://doi.org/10.31083/j.fbl2912420
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejo Nacional de Ciencia y Tecnología