The Putative Antilipogenic Role of NRG4 and ERBB4: First Expression Study on Human Liver Samples
The study demonstrates a decrease in <i>ERBB4</i> and <i>NRG4</i> mRNA expression in the livers of subjects with high BMI but not in those with NAFLD. The correlation of the studied transcripts with major lipogenesis genes was assessed, and on this basis a putative scheme for NRG4-mediated suppression of hepatic <i>de novo</i> lipogenesis was hypothesised, offering new research vectors in this field.
Authors
- Maria Vulf (ORCID: https://orcid.org/0000-0002-4989-045X)
- Н. Д. Газатова (ORCID: https://orcid.org/0000-0002-4646-3436)
- Pavel Ivanov (ORCID: https://orcid.org/0000-0002-7986-7760)
- Л. С. Литвинова (ORCID: https://orcid.org/0000-0001-5231-6910)
- Maria Bograya (ORCID: https://orcid.org/0000-0002-4543-7850)
- L.V. Volkova (ORCID: https://orcid.org/0000-0003-0938-8577)
- Georgy Kuznetsov (ORCID: https://orcid.org/0000-0001-7859-7108)
- Н. М. Тодосенко (ORCID: https://orcid.org/0000-0001-7468-4861)
- Anastasia Minchenko (ORCID: https://orcid.org/0000-0003-2075-2261)
Institutions
- Immanuel Kant Baltic Federal University (RU)
- Moscow University «Synergy» (RU)
- Kaliningrad State Technical University (RU)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2024-12-11
- DOI
- https://doi.org/10.31083/j.fbl2912414
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77