Coherent Changes in Neural Motor Network Activity during Levodopa-Induced Dyskinesia in a Rat Model of Parkinson’s Disease
These findings suggest that levodopa treatment leads to crucial reduction of inhibitory control over motor networks due to a large decline in spiking of most SNpr GABAergic projecting neurons, which causes persistent hyperactivity in motor circuits, leading to the appearance of thalamocortical gamma oscillations and LID.
Authors
- Ivan Mysin (ORCID: https://orcid.org/0000-0001-9992-127X)
- Vladislav V. Minaychev (ORCID: https://orcid.org/0000-0002-8498-4566)
- E. S. Brazhnik
- Lyudmila B. Popova (ORCID: https://orcid.org/0000-0003-1501-9508)
- Н Ю Новиков
Institutions
- Lomonosov Moscow State University (RU)
- Institute of Theoretical and Experimental Biophysics (RU)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2024-12-24
- DOI
- https://doi.org/10.31083/j.jin2312221
- Citations
- 5
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.85