Genomic Profiling Reveals <i>SMARCA4</i> Mutations Are Associated with Shorter Overall and Intracranial Progression-Free Survival in Patients with Melanoma Brain Metastases
Pathogenic SMARCA4 mutations independently predict an association with shorter OS and intracranial PFS in patients with MBM and associate with expression of pathways known to mediate melanoma virulence. These findings add to our understanding of MBM pathogenesis and suggest their potential use as prognostic biomarkers in patients with MBM and possible therapeutic opportunities.
Authors
- Keith Lloyd Ligon (ORCID: https://orcid.org/0000-0002-7733-600X)
- Nayan Lamba
- Ayal Aizer
- Jayne Vogelzang (ORCID: https://orcid.org/0000-0001-8249-3600)
- Grant M. Fischer (ORCID: https://orcid.org/0000-0003-3730-9004)
Institutions
- Brigham and Women's Hospital (US)
- Massachusetts General Hospital (US)
- Dana-Farber Cancer Institute (US)
- Dana-Farber Brigham Cancer Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-0301
- Citations
- 3
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.70