Effect of L-Dopa on cypermethrin induced reproductive conditions in female Japanese quail, Coturnix coturnix japonica

The aim of the present study was to test whether L-Dopa (L-Dihydroxyphenylalanin) treatment can protect cypermethrin induced toxic effect on female reproductive organs in Japanese quail, Coturnix coturnix japonica. The adult female Japanese quail of 6-7 weeks of age and 150-190 gm in weight were divided into four groups (6 birds each). Group-1 received normal saline and served as control. Group-2 received cypermethrin (1mg/kg body weight) dissolved in corn oil. Group-3 received L-Dopa (5mg/100 mg body weight) and Group- 4 received both cypermethrin and L-Dopa. All treatments were given for 30 days. After completion of treatment body weight were recorded. The birds were anesthetized with ether at the end of the experiment. Oviduct and follicles were removed and fixed in bouin’s fluid for further study. Follicles weight, size and number of follicles CYP treated group showed significantly decreased value when compared to control and L-dopa group. L-dopa treated group showed significantly increased value of oviduct weight, follicles weight and size whereas number of follicles were no significantly different when compared to control. CYP + L-dopa fed group showed significantly increased value of follicles weight and decreased number of follicles in comparison to control. Body weight did not show any significant change in the entire experimental group when compared to control. On the basis of the results, it may be concluded that L-Dopa might be a potent protective agent against CYP induced toxic effect on female reproductive conditions in Japanese quail.