Genetic ancestry and risk allele C9orf72 rs3849942 T for amyotrophic lateral sclerosis in Latin American populations
This study examines the relationship between genetic ancestry and the rs3849942 T allele, linked to ALS, in 347 Latin American individuals from the 1000 Genomes Project. Ancestry proportions were estimated using 446 AIMs, and associations were analyzed via logistic regression. Higher Native American ancestry significantly reduced the likelihood of carrying the T allele, while European ancestry increased it. These findings emphasize the importance of incorporating genetic diversity into ALS research.
Authors
- Patricia Lillo (ORCID: https://orcid.org/0000-0001-7398-7203)
- Sergio Flores (ORCID: https://orcid.org/0000-0002-6911-4597)
- Román M. Montaña (ORCID: https://orcid.org/0000-0003-0329-2232)
- Ángel Roco-Videla
- Alejandro Levi-Monsalve
Institutions
- Universidad Autónoma de Chile (CL)
- Universidad Católica de la Santísima Concepción (CL)
- Hospital de São José (PT)
- Center for Climate and Resilience Research (CL)
- University of Chile (CL)
- Arturo Prat University (CL)
Publication Details
- Journal
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1080/21678421.2024.2447459
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00